本文選題：金黃色葡萄球菌　切入點(diǎn)：醫(yī)院感染　出處：《中華醫(yī)院感染學(xué)雜志》2016年01期 　論文類型：期刊論文

【摘要】：目的分析醫(yī)院2011-2014年金黃色葡萄球菌(SAU)分布及耐藥性,為抗菌藥物合理選用提供參考。方法收集醫(yī)院2011年1月-2014年12月臨床分離的SAU,并使用MicroScan WalkAway96plus全自動(dòng)微生物分析儀進(jìn)行鑒定及藥敏試驗(yàn),采用WHONET5.5軟件對(duì)病原菌資料進(jìn)行回顧性分析。結(jié)果共分離SAU913株,其中耐甲氧西林金黃色葡萄球菌(MRSA)407株,檢出率為44.58%,MRSA的檢出率自2011年的45.65%降至2014年的38.03%,呈顯著下降趨勢(shì);SAU主要分布于骨科287株占31.44%、神經(jīng)外科203株占22.23%、燒傷科118株占12.92%和ICU 105株占11.50%,其中燒傷科MRSA的檢出率連續(xù)4年均高于73.10%,明顯高于其他病區(qū);各類臨床標(biāo)本中分泌物標(biāo)本中分離的SAU最高467株,占51.15%,其次痰標(biāo)本335株,占36.69%;MRSA對(duì)常用的抗菌藥物均有較高的耐藥率,但對(duì)慶大霉素、環(huán)丙沙星、左氧氟沙星的耐藥率呈明顯下降趨勢(shì)。結(jié)論 SAU的臨床分離率呈上升趨勢(shì),應(yīng)加強(qiáng)對(duì)其耐藥性監(jiān)測(cè),以指導(dǎo)臨床合理用藥,并有效控制MRSA的醫(yī)院感染。
[Abstract]:Objective to analyze the distribution and drug resistance of Staphylococcus aureus (Staphylococcus aureus) in hospital from 2011 to 2014. Methods the clinical isolates of SAU from January 2011 to December 2014 in hospital were collected, and MicroScan WalkAway96plus automatic microbiological analyzer was used for identification and drug sensitivity test. The data of pathogenic bacteria were analyzed retrospectively by WHONET5.5 software. Results A total of 407 strains of SAU913 were isolated, including 407 strains of methicillin-resistant Staphylococcus aureus. The detectable rate of MRSA decreased from 45.65% on 2011 to 38.03 on 2014. The positive rate of sau mainly distributed in orthopedics 287strains (31.4444), neurosurgery 203strains (22.23234d), burn department 118strains (12.92% strains) and ICU 105strains (11.50g). The detection rate of MRSA in burn department was 11.50%. For 4 consecutive years, it was higher than 73.10, which was obviously higher than that in other areas. There were 467 strains of SAU isolated from all kinds of clinical specimens, accounting for 51.15 strains, followed by 335 strains of sputum, accounting for 36.69% of MRSA, but they were resistant to gentamicin and ciprofloxacin. Conclusion the clinical isolation rate of SAU is on the rise, so it is necessary to strengthen the monitoring of drug resistance in order to guide rational drug use in clinic and to effectively control nosocomial infection of MRSA.
【作者單位】： 解放軍第98醫(yī)院檢驗(yàn)科;杭州市余杭區(qū)中醫(yī)院檢驗(yàn)科;
【基金】：杭州市醫(yī)療衛(wèi)生科研基金資助項(xiàng)目(20140633B56)
【分類號(hào)】：R446.5

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