發(fā)布時(shí)間：2018-03-09 12:33

  本文選題：肺炎鏈球菌　切入點(diǎn)：耐藥性　出處：《中國抗生素雜志》2016年01期 　論文類型：期刊論文

【摘要】：目的了解重慶地區(qū)兒童2009—2014年肺炎鏈球菌對(duì)常用抗菌藥物的耐藥性及血清型分布。方法分析2009—2014年從臨床感染患者標(biāo)本中檢出的11671株肺炎鏈球菌的分布特征,采用BD Phoenix 100測定肺炎鏈球菌對(duì)18種抗菌藥物的藥敏試驗(yàn),按美國臨床實(shí)驗(yàn)室標(biāo)準(zhǔn)化委員會(huì)(CLSI)標(biāo)準(zhǔn)判斷結(jié)果。莢膜腫脹試驗(yàn)進(jìn)行血清學(xué)分型,并計(jì)算疫苗(PCV 7、PCV 11、PCV 13)覆蓋率。結(jié)果 6年共分離肺炎鏈球菌11671株,檢出率為14.37%;2歲組肺炎鏈球菌分離率為50.7%,2~5歲和5歲組的分離率30.8%和18.5%,81.5%的分離株在≤5歲年齡段;未檢出耐萬古霉素和替考拉寧的肺炎鏈球菌。肺炎鏈球菌對(duì)利奈唑胺、左氧氟沙星、氧氟沙星、利福平和泰利霉素的耐藥率低,分別為:0.02%、0.21%、0.08%、1.13%和3.15%;對(duì)四環(huán)素、阿奇霉素、紅霉素、克林霉素、復(fù)方磺胺甲VA唑的耐藥率均70%以上。2009—2014年肺炎鏈球菌對(duì)美羅培南、左氧氟沙星和利奈唑胺的耐藥率無明顯改變(P0.05),其余受試藥物的耐藥率均有明顯改變(P0.05)。600株肺炎鏈球菌共鑒定出20個(gè)血清型,常見的肺炎鏈球菌血清型為19F、19A、6B、23F,PCV 13覆蓋率為75.5%。結(jié)論肺炎鏈球菌是導(dǎo)致重慶地區(qū)兒童呼吸道感染的重要病原菌,對(duì)不同抗生素的耐藥性不同,并隨著時(shí)間而變化,應(yīng)重視細(xì)菌耐藥性監(jiān)測,根據(jù)藥敏試驗(yàn)結(jié)果合理選用抗菌藥物。重慶地區(qū)肺炎鏈球菌臨床分離株以19F、19A、6B、23F血清型為主,推薦PCV 13疫苗預(yù)防肺炎鏈球菌感染。
[Abstract]:Objective to investigate the drug resistance and serotype distribution of Streptococcus pneumoniae from 2009 to 2014 in Chongqing area. Methods the distribution characteristics of 11671 strains of Streptococcus pneumoniae isolated from clinical infected patients in 2009-2014 were analyzed. The susceptibility test of Streptococcus pneumoniae to 18 kinds of antimicrobial agents was determined by BD Phoenix 100, and the results were judged according to the standard of American Clinical Laboratory Standardization Committee. Results 11671 strains of Streptococcus pneumoniae were isolated in 6 years. The detection rate was 14.3710%. The isolation rate of Streptococcus pneumoniae was 50.7% in the group of 5 and 5 years of age, and 81.5% of the isolates were in the age group of 鈮，

本文編號(hào)：1588572