本文關(guān)鍵詞：臨床分離金黃色葡萄球菌的藥物敏感性分析　出處：《中華醫(yī)院感染學(xué)雜志》2016年02期 　論文類(lèi)型：期刊論文

  更多相關(guān)文章： 金黃色葡萄球菌 耐甲氧西林金黃色葡萄球菌 藥敏試驗(yàn)

【摘要】：目的調(diào)查金黃色葡萄球菌在臨床標(biāo)本中的分布及對(duì)抗菌藥物的敏感性,為臨床醫(yī)師預(yù)防感染、選擇藥物提供可靠的參考依據(jù)。方法收集2013年1-12月臨床科室送檢標(biāo)本中分離的480株金黃色葡萄球菌,采用法國(guó)生物梅里埃公司VITEK-2全自動(dòng)微生物分析系統(tǒng)進(jìn)行藥敏試驗(yàn);采用SPSS15.0軟件進(jìn)行統(tǒng)計(jì)分析。結(jié)果 480株金黃色葡萄球菌中耐甲氧西林金黃色葡萄球菌(MRSA)108株占22.5%,甲氧西林敏感金黃色葡萄球菌(MSSA)372株占77.5%;痰標(biāo)本MRSA檢出率最高,達(dá)82.1%,其次為尿液、血液、引流液、皮膚組織,檢出率分別為42.9%、21.2%、16.9%和10.4%;未發(fā)現(xiàn)耐萬(wàn)古霉素和利奈唑胺金黃色葡萄球菌,金黃色葡萄球菌對(duì)磺胺甲VA唑/甲氧芐啶、呋喃妥因和利福平的敏感率較高,皮膚組織來(lái)源的MRSA對(duì)慶大霉素、環(huán)丙沙星、左氧氟沙星、利福平、莫西沙星和四環(huán)素的敏感率明顯高于其他標(biāo)本來(lái)源的MRSA(P0.05);皮膚組織來(lái)源的MRSA對(duì)紅霉素、克林霉素和磺胺甲VA唑/甲氧芐啶的敏感率明顯低于其他標(biāo)本來(lái)源的MRSA(P0.05);MRSA對(duì)青霉素的耐藥率為100.0%。結(jié)論金黃色葡萄球菌是臨床感染標(biāo)本中的重要病原菌,耐藥率高,臨床醫(yī)師應(yīng)根據(jù)藥敏試驗(yàn)結(jié)果合理使用抗菌藥物。
[Abstract]:Objective to investigate the distribution of Staphylococcus aureus in clinical specimens and its sensitivity to antimicrobial agents in order to prevent infection for clinicians. Methods 480 strains of Staphylococcus aureus isolated from clinical samples from 2013 to December were collected. The drug sensitivity test was carried out with the VITEK-2 automatic microbiological analysis system of Bio-Merriere Company of France. Results 22.5% of the 480 strains of Staphylococcus aureus were methicillin-resistant Staphylococcus aureus. Methicillin-sensitive Staphylococcus aureus (MSSA) 372 strains accounted for 77.5%; The detection rate of MRSA in sputum was the highest (82.1%), followed by urine, blood, drainage fluid and skin tissue. The detection rate was 42.9% and 10.4%, respectively. Vancomycin resistant staphylococcus aureus and rifampicin were not found. Staphylococcus aureus was sensitive to sulfamethazol / trimethoprim furantoin and rifampicin. The sensitivity of skin tissue derived MRSA to gentamicin, ciprofloxacin, levofloxacin, rifampicin, moxifloxacin and tetracycline was significantly higher than that of other specimens. The sensitivity of skin tissue derived MRSA to erythromycin, clindamycin and sulfamethazol / trimethoprim was significantly lower than that of other specimens. The resistance rate of MRSA to penicillin was 100.00.Conclusion Staphylococcus aureus is one of the most important pathogens in clinical infection, and the drug resistance rate is high. The clinician should use antibiotics reasonably according to the results of drug sensitivity test.
【作者單位】： 開(kāi)封市中心醫(yī)院檢驗(yàn)科;河南省淮河醫(yī)院檢驗(yàn)科;
【基金】：河南省衛(wèi)生廳基金資助項(xiàng)目(2010ZRZD05)
【分類(lèi)號(hào)】：R446.5
【正文快照】： 隨著β-內(nèi)酰胺類(lèi)抗菌藥物在臨床上的廣泛應(yīng)用,耐甲氧西林金黃色葡萄球菌(MRSA)在金黃色 葡萄球菌中所占比例逐年上升,MRSA不僅具有嚴(yán)2　結(jié)　果重的耐藥性,而且不同地區(qū)、不同時(shí)期、不同醫(yī)院,其耐藥性也各不相同[1-2]。為了探討醫(yī)院金黃色葡萄2.1　不同標(biāo)本MRSA檢出率　從480

【相似文獻(xiàn)】

相關(guān)期刊論文 前10條

1 白潔;機(jī)組配餐員的金黃色葡萄球菌污染情況[J];國(guó)外醫(yī)學(xué)(衛(wèi)生學(xué)分冊(cè));2002年02期

2 朱自強(qiáng);;金黃色葡萄球菌更具殺傷力的原因在于其金黃色“外殼”[J];基礎(chǔ)醫(yī)學(xué)與臨床;2005年11期

3 杜洪利;張雙雙;歐旭;閆訓(xùn)友;;金黃色葡萄球菌檢測(cè)技術(shù)研究進(jìn)展[J];食品與發(fā)酵科技;2009年05期

4 黃嶺芳;賴(lài)衛(wèi)華;張莉莉;;食品中金黃色葡萄球菌快速檢測(cè)方法的研究進(jìn)展[J];食品與機(jī)械;2009年06期

5 王娉;勞華均;胡s，

本文編號(hào)：1434965