本文關(guān)鍵詞：基于磁共振的人體體內(nèi)鐵沉積量的相關(guān)性研究　出處：《沈陽工業(yè)大學(xué)》2015年碩士論文　論文類型：學(xué)位論文

  更多相關(guān)文章： 磁共振成像 磁敏感定量成像 鐵沉積 地中海貧血病

【摘要】：本文基于磁共振磁敏感定量成像（Quantitative Susceptibility Mapping，QSM）和T2*加權(quán)成像的方法，評(píng)估地中海貧血病患者的肝臟，心臟，大腦的鐵沉積量。研究患者各個(gè)器官內(nèi)鐵沉積量與體內(nèi)鐵沉積量的相關(guān)性以及患者肝臟、心臟、大腦的鐵沉積量與年齡的相關(guān)性，并對(duì)比磁敏感定量成像和T2*兩種成像方法的可行性。本文收集33例地中海貧血病患者進(jìn)行梯度回波序列的大腦磁共振掃描，獲得磁敏感定量成像和T2*方法需要的圖像數(shù)據(jù)，再經(jīng)過一系列后處理過程計(jì)算器官內(nèi)的鐵沉積量，并進(jìn)行相關(guān)性研究。研究結(jié)果表明用磁敏感定量成像和T2*方法得到的圖像都可以明顯看出器官內(nèi)鐵元素的分布情況，其中，T2*方法是對(duì)心臟、肝臟等其器官進(jìn)行成像的較好方法，因?yàn)槠涑上袼俣瓤烨夷軌蚝芎玫目刂坪粑鼈斡埃�，但�?duì)于腦鐵含量的檢測(cè)，T2*加權(quán)方法的敏感性較差；而磁敏感定量成像方法，可以快速、準(zhǔn)確地定量出腦鐵含量。另外，對(duì)于相關(guān)性的研究表明心臟、肝臟、大腦的鐵沉積量與體內(nèi)鐵沉積量線性相關(guān)；心臟、肝臟的鐵沉積量與大腦鐵沉積量線性相關(guān)；心臟、肝臟、大腦的鐵沉積量與患者年齡無關(guān)。本文通過研究發(fā)現(xiàn)應(yīng)用T2*方法和磁敏感定量成像方法都能很有效地評(píng)估組織成分的常規(guī)非侵入性，尤其是對(duì)鐵的檢測(cè)，對(duì)于不同的身體器官，應(yīng)用不同的方法，或者對(duì)患者進(jìn)行兩種方法的整體檢查，將有助于臨床的預(yù)防或進(jìn)行早期診斷治療，這對(duì)評(píng)估地中海貧血病是非常重要的。
[Abstract]:In this paper, magnetic resonance imaging based on quantitative magnetic susceptibility (Quantitative Susceptibility, Mapping, QSM) and T2* weighted imaging method, assessment of Mediterranean anemia in patients with liver, heart, brain iron deposition in various organs. Research on patients with iron deposition and iron deposition and the correlation between the patients with liver, heart, and the relationship between iron deposition the age of the brain, and the feasibility of contrast magnetic sensitive quantitative imaging and T2* two imaging methods. The brain MRI scan, we collected 33 cases of thalassemia patients with gradient echo sequence, magnetic sensitive image data to quantitative imaging and T2* method, then through a series of postprocessing iron deposition process calculating inside, and the correlation was studied. The research results show that the image obtained by magnetic sensitive quantitative imaging and T2* method can obviously see distribution of iron in organs The condition, T2* method is good for the heart, liver and other organs of the imaging method, because of its fast imaging speed and can control breathing artifact is very good, but for the detection of brain iron content, the poor sensitivity of T2* weighted method; and the magnetic sensitive quantitative imaging method can quickly and accurately quantify the brain iron content. In addition, the correlation study shows that the heart, liver, iron deposition and iron deposition in the brain heart, linear correlation; iron deposition and brain iron deposition in liver of linear related; the heart, liver, brain iron deposition has nothing to do with the age of patients through the study found that the application of T2*. Method and magnetic sensitive quantitative imaging method can effectively evaluate the composition of conventional non-invasive detection, especially for iron, for different body organs, applying different methods, two kinds of methods or for patients Overall examination will contribute to the prevention of clinical or early diagnosis and treatment, which is very important for assessing thalassemia.

【學(xué)位授予單位】：沈陽工業(yè)大學(xué)
【學(xué)位級(jí)別】：碩士
【學(xué)位授予年份】：2015
【分類號(hào)】：R445.2

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