發(fā)布時間：2018-04-11 01:21

  本文選題：動脈粥樣硬化 + 用戶自定義函數(shù)　； 參考：《醫(yī)用生物力學(xué)》2017年04期

【摘要】：目的通過在FLUENT計算流體動力學(xué)分析軟件中調(diào)用自主開發(fā)的用戶自定義函數(shù)(user defined function,UDF)動網(wǎng)格程序,實現(xiàn)網(wǎng)格節(jié)點根據(jù)壁面切應(yīng)力(wall shear stress,WSS)判據(jù)進行移動更新,并將此方法應(yīng)用于模擬動脈粥樣硬化(atherosclerosis,AS)的發(fā)展過程中。方法二次開發(fā)的UDF程序能夠在計算過程中提取壁面各節(jié)點處WSS結(jié)果,若滿足閾值判據(jù)條件則進行移動調(diào)整。采用彈性光順與局部重構(gòu)相結(jié)合的網(wǎng)格再生方法調(diào)控網(wǎng)格模型的更新,保證變形過程中的網(wǎng)格質(zhì)量。結(jié)果 UDF程序成功提取出WSS并調(diào)整網(wǎng)格進行相應(yīng)變形。初始狹窄造成的尾部渦流導(dǎo)致血管壁出現(xiàn)近端局部擴張,遠端再狹窄的形貌特征,臨床血管造影存在相似形貌。結(jié)論自主開發(fā)的UDF程序達到了預(yù)期效果,勾勒出了WSS影響下AS的形貌特征。在今后研究中可以考慮在動網(wǎng)格的變形控制方面添加更多影響因素,為AS臨床預(yù)后及風(fēng)險評測提供數(shù)值依據(jù)。
[Abstract]:Aim by calling the self-developed user defined function (UDF) dynamic grid program in the FLUENT computational fluid dynamics analysis software, the grid node can be moved and updated according to the wall shear stress wall shear stress WSS criterion.The method was applied to the development of atherosclerotic ASA.Methods the second developed UDF program can extract the WSS results at every node on the wall in the course of calculation, and adjust the motion if the threshold criterion condition is satisfied.The mesh regeneration method combined with elastic fairing and local reconstruction is used to control the updating of the mesh model to ensure the mesh quality in the process of deformation.Results UDF program successfully extracted WSS and adjusted the mesh for corresponding deformation.The initial stenosis resulted in local dilatation of the proximal end of the vascular wall and the appearance of distal restenosis, and the appearance of clinical angiography was similar.Conclusion the self-developed UDF program achieves the desired effect and outlines the morphological characteristics of as under the influence of WSS.In the future research, we can add more factors to the deformation control of dynamic mesh, and provide the numerical basis for the clinical prognosis and risk assessment of as.
【作者單位】： 鄭州大學(xué)力學(xué)與工程科學(xué)學(xué)院微納成型技術(shù)國家級國際聯(lián)合研究中心;
【基金】：國家國際科技合作專項(2015DFA30550) 國家高端外國專家項目(20154100007) 河南省國際科技合作項目(152102410013) 河南省高等學(xué)�？蒲袆�(chuàng)新團隊(14IRTSTHN001)
【分類號】：R543.5;TP393.02
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本文編號：1733806